User:ElNando888/Static Cloud Labs/CL-V.Can we do it in 10

From Eterna Wiki

The experiment I'm proposing has few chances to be selected, as it promises to score bad. Still, following the same path as I did in my blog post about exploring FRABASE, I searched for and selected a naturally occurring multiloop.

 

2E5L multiloop.png

 

This picture is simply meant to illustrate the fact that RNA seems to like to form stacks, even in multioops, and even if they have to jump from a strand to another.

Obviously, there will be many interactions inside the loop, promising a number of SHAPE-protected bases where the game would like to see reactive ones, and clearly, this design can't score very well in these conditions.

 

Still, I'd be curious to see the SHAPE data associated with this multiloop.

 

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